janneuf: Hey, I hear ya buddy. My personal primary choice is the .270 Win for deer and antelope, sometimes coyotes. As I started out with that caliber over 40 years ago, and it has never failed me, it's hard to change (old dog, new trick thingie...).
However, when I want to feel fresh and have that sense of adventure you mention, that's when I grab my titanium M700 clone (Mdl 15 Ti, Prairie Gunworks, Canada) chambered in 7mm-08 Ackley, and hit the mountain. It about duplicates my old .270 Win, shoots tighter groups, and is three pounds lighter.
I know what you mean, and that's how I add the sense of being different, and the spice of adventure to something I've been doing and loving to do for a long time. Both ways work, this is just my way of getting it done with a smile.
